RESUMO
Epigenetics refers to heritable changes in gene expression and function without alterations in gene sequences,including DNA methylation,histone modification,and non-coding RNAs.Endometriosis is a benign gynecological disease that affects the fertility and health of reproductive-age women,the etiology of which remains unclear.The recent studies have demonstrated that epigenetics plays a key role in the occurrence and development of endometriosis.This article reviews the research progress in the regulatory mechanism and application of epigenetics in endometriosis.
Assuntos
Feminino , Humanos , Endometriose/genética , Epigênese Genética , Metilação de DNA , Processamento de Proteína Pós-TraducionalRESUMO
Ventricular arrhythmias in pregnancy is a common disease of cardiovascular disease during pregnancy which can cause adverse outcomes in severe state,such as maternal heart failure,sudden death,fetal hypoxia,premature delivery and stillbirth.The management of ventricular arrhythmias requires multidisciplinary participation,including obstetrics,cardiology,anesthesiology and neonatology.This article discusses how to manage the ventricular arrhythmias from the following aspects:pre-pregnancy counseling and assessment,treatments,managements during pregnancy and managements of delivery in order to reduce the occurrence of maternal and fetal complications,and emphasizes the significance of multidisciplinary collaborative management to the prognosis of disease.